There is a possible mouse model that may be helpful in developing understanding of the mechanisms underlying the observed resistance. i.e. there are strains of mice that are tolerant and others that are highly susceptible to the disease.
In this project microarray data from different mouse strains and different tissues were integrated with a mouse protein interaction network.
Functional groups in a mouse protein interaction network
The network was analysed using Cytoscape (Shannon et al., 2003) and its plugins, so building on skills developed in the modules Introduction to Microarray Data Analysis and Bioinformatics for Systems Biology.
Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T.
Cytoscape: a software environment for integrated models of biomolecular interaction networks.
Genome Research 2003 Nov; 13(11):2498-504
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